Table 3.
Inhibition activities (IC50, μM a) of all compounds against epidermal growth factor receptor (EGFR).
Compounds | IC50, μM a | Compounds | IC50, μM a |
---|---|---|---|
H1 | 8.47 | H17 | 7.89 |
H2 | 0.65 | H18 | 0.48 |
H3 | 2.12 | H19 | 1.25 |
H4 | 0.23 | H20 | 0.08 |
H5 | 4.31 | H21 | 3.56 |
H6 | 5.96 | H22 | 5.07 |
H7 | 26.94 | H23 | 24.58 |
H8 | 7.20 | H24 | 6.65 |
H9 | 16.20 | H25 | 15.33 |
H10 | 19.95 | H26 | 18.55 |
H11 | 14.10 | H27 | 13.78 |
H12 | 12.81 | H28 | 12.34 |
H13 | 11.86 | H29 | 11.24 |
H14 | 10.33 | H30 | 10.02 |
H15 | 9.87 | H31 | 9.66 |
H16 | 9.01 | H32 | 8.64 |
Erlotinib | 0.03 |
a EGFR inhibitory activity was measured by the solid-phase ELISA assay. Values are the average of six independent experiments run in triplicate. Variation was generally 5%–10%.