Table 3.
Levels of dRNs in HepG2 cells of every group (pmol/106 cell).
| MRM Transition | Control | F | P | P-F | |
|---|---|---|---|---|---|
| dATP | 490.0→159.1 | 30.34 ± 0.5 | 113.11 ± 10.2 ** | 32.45 ± 1.8 * | 126.9 ± 16.4 ** |
| dADP | 410.0→79.0 | 0.0568 ± 0.005 | 0.2789 ± 0.02 ** | 0.0526 ± 0.003 | 0.3414 ± 0.05 **,# |
| dAMP | 330.0→79.0 | 0.0068 ± 0.002 | 0.0354 ± 0.003 ** | 0.007 ± 0.001 | 0.0525 ± 0.01**,## |
| dCTP | 465.9→159.0 | 28.48 ± 0.6 | 138.3 ± 12.3 ** | 24.00 ± 1.8 ** | 126.6 ± 18.8 ** |
| dCDP | 386.0→79.0 | 0.0297 ± 0.005 | 0.1185 ± 0.01 ** | 0.0189 ± 0.002 ** | 0.1446 ± 0.03 ** |
| dCMP | 306.0→79.0 | 0.0499 ± 0.006 | 0.0394 ± 0.007 * | 0.0304 ± 0.008 ** | 0.0923 ± 0.016 **,## |
| dGTP | 581.0→152.1 | 40.35 ± 2.3 | 12.81 ± 0.50 ** | 34.22 ± 3.4 ** | 9.52 ± 0.84 **,## |
| dGDP | 501.0→152.0 | 2.12 ± 0.09 | 0.13 ± 0.07 ** | 2.22 ± 0.4 | 0.13 ± 0.06 ** |
| dGMP | 421.0→152.0 | 2.92 ± 0.1 | 0.28 ± 0.07 ** | 2.72 ± 0.4 | 0.35 ± 0.09 ** |
| dUTP | 467.0→159.0 | *UDL | *UDL | *UDL | *UDL |
| dUDP | 387.0→79.0 | 0.02 ± 0.01 | 0.22 ± 0.07 ** | 1.52 ± 3.4 | 0.59 ± 0.39 **,# |
| dUMP | 307.0→79.0 | 0.17 ± 0.03 | 76.38 ± 5.7 ** | 0.15 ± 0.05 | 137.79 ± 17.3 **,## |
| dTTP | 481.0→159.1 | 85.54 ± 1.0 | 40.61 ± 3.0 ** | 92.77 ± 7.2 * | 15.73 ± 1.8 **,## |
| dTDP | 401.0→79.0 | 2.66 ± 0.2 | 1.25 ± 0.05 ** | 3.11 ± 0.1 ** | 1.14 ± 0.07 **,## |
| dTMP | 321.0→79.0 | 0.0435 ± 0.005 | 0.004 ± 0.0008 ** | 0.049 ± 0.003 * | 0.0071 ± 0.004 ** |
Note: All data were expressed as mean ± SD values by three independent experiments. P value of less than 0.05 (* p < 0.05, ** p < 0.01, versus the control group; # p < 0.05, ## p < 0.01, compared with the 5-FU group) are considered significant; *UDL, under detected limit of assay.