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In vivo skin irritation examination. Changes in TEWL value before and after 24 h application of the selected silymarin creams III, IV, VIII, IX on the dorsal skin of guinea pigs. Each data point represents the mean ± S.D., n = 5. Repeated-Measures ANOVA and Pearson correlation tests were performed. Significant differences were marked with *, which show the significance levels in the case of compositions VIII and IX before and after 24 h compared to the untreated controls.
