. 2016 May 19;21(5):650. doi: 10.3390/molecules21050650

Table 1.

Update of novel radioligands for PET imaging of PDEs 2, 4, 5, 7, and 10 since 2012.

Phosphodiesterase	Radioligands Review Compound No. (Code No. Given)	References
PDE2	[¹⁸F]1 ([¹⁸F]B-23)	[48,55]
	[¹⁸F]2 ([¹⁸F]PF-05270430)	[48,56,57,58]
	[¹⁸F]3, [¹⁸F]4, [¹⁸F]5 ([¹⁸F]TA3–5)	[60,61,62]
PDE4	[¹⁸F]7 ([¹⁸F]MNI-617)	[82]
PDE5	[¹¹C]8 ([¹¹C]sildenafil), [¹⁸F]13, [¹¹C]14, [¹¹C]16, [¹¹C]17	[97]
PDE5	[¹⁸F]18 ([¹⁸F]ICF24027)	[110]
PDE7	[¹⁸F]20 ([¹⁸F]MICA-003), [¹¹C]21 ([¹¹C]MICA-005)	[121,122]
PDE10	Structurally related to compound 22 (MP-10)
	[¹⁸F]26, [¹¹C]29	[143]
	[¹¹C]30 ([¹¹C]TZ1964B), [¹¹C]31–33	[157,160]
	[¹⁸F]34–40	[158]
	[¹¹C]42	[161]
	Structurally not derived from compound 22 (MP-10)
	[¹⁸F]47 ([¹⁸F]AQ28A)	[170,172]
	[¹⁸F]48 ([¹⁸F]MNI-654), [¹⁸F]49 ([¹⁸F]MNI-659)	[175,176,177,178]
	[¹¹C]50 ([¹¹C]IMA104), [¹¹C]51 ([¹¹C]IMA106)	[142,181]
	[¹¹C]52 ([¹¹C]IMA107), [¹⁸F]53 ([¹⁸F]IMA102)
	[¹¹C]54 ([¹¹C]Lu AE92686)	[182,183]
	[¹¹C]55 ([¹¹C]AMG 7980), [¹⁸F]56 ([¹⁸F]AMG 580)	[185,186,187]
	[¹¹C]58–60, [¹¹C]61 ([¹¹C]T-773), [¹¹C]62–64	[190,191,192,193,194]
	[¹¹C]66 ([¹¹C]MK-8193), [¹¹C]67–69	[196,197,199]