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. 2016 Sep 20;21(9):1252. doi: 10.3390/molecules21091252

Table 1.

Phytochemicals against CIPN.

Phytochemical Dose Chemotherapy Effects Refs.
Auraptenol
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0.05–0.8 mg/kg Vincristine in mice Suppresses mechanical hyperalgesia and alteration of behavioral and biochemical changes [22]
Cannabidiol
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2.5–10 mg/kg Paclitaxel in mice Inhibits neuropathic pain through 5-HT1A receptor signaling without diminishing chemothferapy efficacy or nervous system function [23]
Curcumin
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10 mg/kg Cisplatin or oxaliplatin in rats Reverses the alterations of neurotensin levels in the plasma, protects the sciatic nerve from injury, and reduces drug absorption in the sciatic nerve [24]
Rutin
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& quercetin
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25–100 mg/kg Oxaliplatin in rats prevent the shrinkage of neurons and inhibit edema [25]
Verticinone
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1.5–3 mg/kg Paclitaxel in rats Has a relatively constant analgesic effect; the analgesic effect of morphine was decreased after repeated medication [26]
Xylopic acid
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10–100 mg/kg Vincristine in rats Has anti-allodynic and anti-hyperalgesic properties [27]