Table 1.

Phytochemicals against CIPN.

Phytochemical	Dose	Chemotherapy	Effects	Refs.
Auraptenol	0.05–0.8 mg/kg	Vincristine in mice	Suppresses mechanical hyperalgesia and alteration of behavioral and biochemical changes	[22]
Cannabidiol	2.5–10 mg/kg	Paclitaxel in mice	Inhibits neuropathic pain through 5-HT1A receptor signaling without diminishing chemothferapy efficacy or nervous system function	[23]
Curcumin	10 mg/kg	Cisplatin or oxaliplatin in rats	Reverses the alterations of neurotensin levels in the plasma, protects the sciatic nerve from injury, and reduces drug absorption in the sciatic nerve	[24]
Rutin & quercetin	25–100 mg/kg	Oxaliplatin in rats	prevent the shrinkage of neurons and inhibit edema	[25]
Verticinone	1.5–3 mg/kg	Paclitaxel in rats	Has a relatively constant analgesic effect; the analgesic effect of morphine was decreased after repeated medication	[26]
Xylopic acid	10–100 mg/kg	Vincristine in rats	Has anti-allodynic and anti-hyperalgesic properties	[27]