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. 2016 Sep 20;21(9):1252. doi: 10.3390/molecules21091252

Table 2.

Medicinal herbs against CIPN.

Herbs Dose Chemotherapy Effects Refs.
Acorus calamus 100–200 mg/kg Vincristine in rats Attenuates symptoms of neuropathy through serotonin 5-HT1A receptors [28]
Butea monosperma 200–400 mg/kg Vincristine in rats Reverses alterations of behavioral, biochemical, and histopathological changes [29]
Ginkgo biloba L. 50–150 mg/kg Vincristine in rats Decreases paw-withdrawal frequency to cold stimuli and increases the threshold to mechanical stimuli
Suppresses NF-κB activation and production of TNF-α and NO
Inhibits axonal degradation
Improves axonal transportation
[30]
100–200 mg/kg Cisplatin in rats, mice, guinea pigs Protects the inner ear from ototoxicity [31]
Camellia sinensis 300 mg/kg Oxaliplatin in rats Alleviates mechanical allodynia and thermal hyperalgesia, but does not prevent morphometric or electrophysiological alterations [32]
Ocimum sanctum 100–200 mg/kg Vincristine in rats Attenuates neurotoxicity with the decline in calcium levels and oxidative stress [33]
Salvia officinalis 100 mg/kg Cisplatin in mice, Suppresses a second phase of cisplatin-enhanced pain in the formalin test [34]
Walnut 6% of diet Cisplatin in rats Inhibits an alteration in performance of hippocampus- and cerebellum-related behaviors [35]
Xylopia aethiopica 30–300 mg/kg Vincristine in rats Has anti-allodynic and anti-hyperalgesic properties [27]