Table 2.

Medicinal herbs against CIPN.

Herbs	Dose	Chemotherapy	Effects	Refs.
Acorus calamus	100–200 mg/kg	Vincristine in rats	Attenuates symptoms of neuropathy through serotonin 5-HT1A receptors	[28]
Butea monosperma	200–400 mg/kg	Vincristine in rats	Reverses alterations of behavioral, biochemical, and histopathological changes	[29]
Ginkgo biloba L.	50–150 mg/kg	Vincristine in rats	Decreases paw-withdrawal frequency to cold stimuli and increases the threshold to mechanical stimuli Suppresses NF-κB activation and production of TNF-α and NO Inhibits axonal degradation Improves axonal transportation	[30]
	100–200 mg/kg	Cisplatin in rats, mice, guinea pigs	Protects the inner ear from ototoxicity	[31]
Camellia sinensis	300 mg/kg	Oxaliplatin in rats	Alleviates mechanical allodynia and thermal hyperalgesia, but does not prevent morphometric or electrophysiological alterations	[32]
Ocimum sanctum	100–200 mg/kg	Vincristine in rats	Attenuates neurotoxicity with the decline in calcium levels and oxidative stress	[33]
Salvia officinalis	100 mg/kg	Cisplatin in mice,	Suppresses a second phase of cisplatin-enhanced pain in the formalin test	[34]
Walnut	6% of diet	Cisplatin in rats	Inhibits an alteration in performance of hippocampus- and cerebellum-related behaviors	[35]
Xylopia aethiopica	30–300 mg/kg	Vincristine in rats	Has anti-allodynic and anti-hyperalgesic properties	[27]