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. 2016 Nov 17;21(11):1520. doi: 10.3390/molecules21111520

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of Sin and 1a–2f on (A) IL1β; (B) IL6; and (C) TNF-α expression in LPS-treated Raw264.7 cells. Raw264.7 cells were treated with 1 µg/mL of LPS (Blank was untreated), followed by 10 µg/mL Sin or 1a–2f for a total of 12 h. The blank and vehicle (Model) samples were treated with an equivalent volume of vehicle. Sin reduced the LPS induced increase in IL6, or TNF-α, while the 1a–2f derivatives significantly reduced all inflammatory cytokines to varying degrees. Results are expressed as mean ± SD (n = 3). * p < 0.05 vs. vehicle (Model); ^# p < 0.05 vs. Sin.

Effect of Sin and 1a–2f on (A) IL1β; (B) IL6; and (C) TNF-α expression in LPS-treated Raw264.7 cells. Raw264.7 cells were treated with 1 µg/mL of LPS (Blank was untreated), followed by 10 µg/mL Sin or 1a–2f for a total of 12 h. The blank and vehicle (Model) samples were treated with an equivalent volume of vehicle. Sin reduced the LPS induced increase in IL6, or TNF-α, while the 1a–2f derivatives significantly reduced all inflammatory cytokines to varying degrees. Results are expressed as mean ± SD (n = 3). * p < 0.05 vs. vehicle (Model); ^# p < 0.05 vs. Sin.