Table 2.
Inhibitory effect of the crude extract and fractions of X. strumarium on α-glucosidase, protein tyrosine phosphatase 1β (PTP1β), advanced glycation end products (AGEs), and ABTS+.
| Entry | Acarbose 1 | Suramin 2 | Aminoguanidine 3 | Trolox 4 | MeOH | CH2Cl2 | EtOAc | n-BuOH | Water |
|---|---|---|---|---|---|---|---|---|---|
| IC50 (μg/mL) 5 | |||||||||
| Positive Control | Extract | Fraction | |||||||
| α-Glucosidase | 377.19 ± 38.17 | - | - | - | >500 | - | 399.66 ± 37.51 | - | - |
| PTP1β | - | 8.96 + 0.83 | - | - | 12.88 ± 1.18 | 20.81 ± 2.09 | 9.80 ± 0.89 | 15.08 ± 1.46 | 28.44 ± 2.79 |
| AGEs | - | - | 166.22 ± 16.29 | - | >200 | >200 | 132.95 ± 12.34 | 168.75 ± 17.87 | - |
| ABTS+ | - | - | - | 7.51 ± 0.58 | 78.32 ± 0.71 | 8.52 ± 0.86 | 9.34 ± 0.92 | 84.47 ± 8.51 | 4.68 ± 4.61 |
1 Acarboseis the positive control for α-glucosidase. 2 Suramin is the positive control for protein tyrosine phosphatase 1β. 3 Aminoguanidine is the positive control for advanced glycation end products. 4 Trolox is the positive control for ABTS+ radical scavenging activity. 5 The IC50 value was defined as the half-maximal inhibitory concentration and mean of 3 duplication analyses of each sample. - is no activity.