Table 4.
Inhibitory effect of isolated compounds from X. strumarium on protein tyrosine phosphatase 1β (PTP1β).
| Entry | Products | Concentration (μg/mL) | Inhibition (%) | IC50 1 (μg/mL) |
|---|---|---|---|---|
| Sumarin 2 | 14.29 | 83.58 | 7.84 ± 0.75 (5.51 μM) | |
| 7.15 | 52.24 | |||
| 3.57 | 26.44 | |||
| 1.43 | 10.45 | |||
| 1 | Protocatechuic acid | 10 | 28.58 | - |
| 2 | 3-Hydroxy-1-(4-hydroxy phenyl) propan-1-one | 10 | 5.88 | - |
| 3 | Cytidine | 10 | - | - |
| 4 | Neochlorogenic acid methyl ester | 10 | 18.79 | - |
| 5 | Chlorogenic acid | 10 | 31.34 | - |
| 6 | Methyl-3,5-di-O-caffeoylquinic acid | 10 | 82.47 | 5.09 ± 0.50 (1.88 μM) |
| 5 | 50.01 | |||
| 2.5 | 30.66 | |||
| 1 | 24.00 | |||
| 7 | Thiazine-3,5-dione-11-O-glucopyranoside | 10 | - | - |
| 8 | Patuletin-3-glucuronide | 10 | - | - |
| 9 | Quercetin-3-O-glucuronide | 10 | 10.71 | - |
| 10 | 3,5-di-O-caffeoylquinic acid | 10 | 18.40 | - |
| 11 | 1,5-di-O-caffeoylquinic acid | 10 | 10.62 | - |
| 12 | 1,3-di-O-caffeoylquinic acid | 10 | 22.34 | - |
| 13 | 1,3,5-tri-O-caffeoylquinic acid | 10 | 39.17 | - |
| 14 | Raffinose | 10 | - | - |
1 The IC50 value was defined as the half-maximal inhibitory concentration and mean of 3 duplication analyses of each sample. 2 Sumarin was used as the positive control. - is no activity.