Figure 5.

The effect of TAU or SF on hepatocyte mitochondrial swelling in iron-overloaded mic Data represents mean ± SE of 12 independent experiments. (A) Ca²⁺-induced mitochondrial swelling in four groups with different treatment. During the onset of mitochondrial swelling, 150 μM Ca²⁺ was added to initiate the reaction. Iron-overload induced mitochondrial swelling, resulted in the large decrease in the absorbance of the mitochondrial suspension at 520 nm in 2 min. However, both SF and TAU inhibited the swelling process; (B) Quantitative analysis of mitochondrial swelling. a: p < 0.01, vs. control group; b: p < 0.01, vs. iron overload group.