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. 2016 Nov 18;21(11):1572. doi: 10.3390/molecules21111572

Table 1.

Structures and cytotoxicity of compounds 5a–i against HT-29, H-460, A-549, and MDA-MB-231 cells in vitro.

Compd. X n R2 R1 IC50 (μM) a
HT-29 H-460 A-549 MDA-MB-231
5a O 2 graphic file with name molecules-21-01572-i001.jpg 2-Cl, 6-CH3 0.15 ± 0.14 0.089 ± 0.11 0.36 ± 0.27 0.75 ± 0.65
5b O 2 graphic file with name molecules-21-01572-i001.jpg 3,4-(CH3)2 1.09 ± 0.21 1.50 ± 0.13 2.33 ± 1.52 2.42 ± 0.28
5c O 3 graphic file with name molecules-21-01572-i002.jpg 2-Cl, 6-CH3 0.36 ± 0.72 0.27 ± 0.12 0.82 ± 0.43 1.08 ± 0.15
5d O 3 graphic file with name molecules-21-01572-i002.jpg 3,4-(CH3)2 1.72 ± 0.37 2.93 ± 0.62 5.46 ± 0.38 3.92 ± 1.24
5e O 3 graphic file with name molecules-21-01572-i002.jpg 4-F 2.64 ± 0.53 1.19 ± 0.96 3.41 ± 1.27 2.72 ± 0.42
5f S 2 graphic file with name molecules-21-01572-i001.jpg 4-Cl 0.24 ± 0.17 0.77 ± 0.22 2.30 ± 0.18 2.59 ± 0.36
5g S 2 graphic file with name molecules-21-01572-i001.jpg 4-OCF3 1.05 ± 0.012 1.28 ± 0.68 2.81 ± 0.73 3.02 ± 0.51
5h S 3 graphic file with name molecules-21-01572-i002.jpg 4-Cl 0.65 ± 0.33 1.02 ± 0.74 1.44 ± 0.39 3.13 ± 0.85
5i S 3 graphic file with name molecules-21-01572-i002.jpg 4-OCF3 2.41 ± 0.21 2.58 ± 0.74 4.86 ± 0.56 4.07 ± 1.02
Sorafenib 3.27 ± 0.32 2.15 ± 0.43 4.47± 0.28 3.81± 0.50

a Results are expressed as means ± SD (standard deviation) of three independent experiments.