Figure 4.

Change in edema thickness using carrageenan-induced rat paw edema mode of compounds 12–19 at 1 h (${}^{▄}$), 2 h (${}^{▄}$) and 3 h (${}^{▄}$) after induction of inflammation; data expressed as mean ± SEM, (n = 6); data were analyzed by One way ANOVA followed by student-Newman-Keuls multiple comparison test; ^a statistically significant from control (p < 0.001); ^b statistically significant from control (p < 0.01); ^c statistically significant from control (p < 0.05).