Table 2.

The anti-inflammatory activity (% inhibition of edema thickness) and ulcer indices of compounds 12–19.

Compd.	% Inhibition in Edema Thickness			Potency a	Ulcerogenicity
	1 h	2 h	3 h		UI b	% Protection c
Control	-	-	-	0	0	100
12	21.20	37.40	44.79	1.10	4.66	66.38
13	16.13	35.43	52.31	1.28	4.41	68.18
14	8.30	9.84	16.37	0.40	4.66	66.38
15	10.60	16.54	24.91	0.61	2.68	80.66
16	29.95	37.80	50.58	1.24	2.26	83.69
17	27.19	40.55	49.47	1.21	2.26	83.69
18	6.91	17.72	22.42	0.55	4.41	68.18
19	13.82	22.44	38.79	0.95	0	100
Ibuprofen	25.81	33.46	40.82	1.00	13.86	0

Anti-inflammatory activity (% inhibition of edema thickness) = (1 − L_t/L_c) × 100; L_t is the mean increase in paw thickness in rats treated with the tested compounds; L_c is the mean increase in paw thickness in control group; ^a Potency = anti-inflammatory activity of tested compound/anti-inflammatory activity of ibuprofen after 3 h of induction of inflammation; ^b Ulcer index (UI) = sum of (% incidence/10), average number of ulcers and average severity; n = 6; ^c percentage protection of ulcer (% inhibition of ulcer relative to ibuprofen) = (UI_St – UI_Test/UI_St) × 100.