Table 2.

GI₅₀ values determined for the TXA1 and TXA1·HCl in various tumor cell lines derived from solid tumors.

Compound	GI50 (µM)
	MCF-7	NCI-H460	A375-C5	HeLa	786-O	Caki-2	AGS
TXA1	6.1 ± 0.4 #	6.0 ± 0.3 #	3.6 ± 1.2 #	6.8 ± 0.5	8.1 ± 1.8	11.5 ± 1.8	35.3 ± 2.3
TXA1·HCl	7.8 ± 0.9	6.9 ± 1.3	3.8 ± 0.8	6.4 ± 0.6	9.0 ± 1.1	9.3 ± 0.8	9.7 ± 0.2

Values presented refer to the mean ± SEM of at least three independent experiments. The maximum vehicles (DMSO for TXA1 and H₂O for TXA1·HCl) concentration used was 0.25% and did not interfere with cell growth (data not shown). Doxorubicin was used as a positive control [GI₅₀ concentrations: 65 ± 8.5 nM in MCF-7, 64 ± 6.8 nM in NCI-H460, 145 ± 9.8 nM in A375-C5, 20.7 ± 0.8 nM in HeLa, 135 ± 6.2 nM in 786-O, 152.3 nM in Caki-2 (from two experiments only), 90 ± 5 nM in AGS]. # data also included in Table 1 as the GI₅₀ concentration of compound 1.