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Scheme of the proposed chemical mechanism for the inhibition of urease enzymes by disulfiram: Empty urease is able to be in the closed or open conformation; (1) DSF binds to CVU in the open conformation and (2) Cys592 thiolate produces the attack to the thiuram group; (3) the enzyme is then modified by DTC moiety and block the flap to achieve the closed conformation; finally, the other DTC moiety is released from the enzyme. Chemical structures were drawn using ACD/ChemSketch®.
