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Comparison of the active sites of M. sativa CHS and O. sativa CUS. (A) CUS catalyzes the condensation between two units of p-coumaroyl-CoA and one unit of malonyl-CoA to form bisdemethoxycurcumin; (B) Schematic representations of the active sites of CUS and CHS. The presence of glycine at position 274 and tyrosine at position 207 orients the active site to allow longer polyketides to be generated.
