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(A) Acyl-binding tunnel in M. tuberculosis PKS18 (PDB ID: 1TED); (B) Myristic acid (from PDB ID: 1TED) superimposed on M. sativa CHS (PDB ID: 1CGK). The residues on the acyl binding tunnel of PKS18 are relatively smaller (A52, S143, C205, A209) and/or more hydrophobic (N208, H221, L266, L348).
