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Acyl-binding tunnel of the following type III PKSs: M. tuberculosis PKS18 (blue, PDB ID: 1TED), E. siliculosus PhlD (pink, PDB ID: 4B0N), and N. crassa ORAS (green, PDB ID: 3EUT). The table shows the residues lining the acyl-binding tunnel of the respective PKSs. PKS18 and PhlD are more similar compared to ORAS; it is possible that these changes lining the acyl-binding tunnel lead to a different product chemistry in ORAS compared to PKS18 and PhlD.
