Scheme 2.
The synthetic route of title compounds. Reagents and Condition: i. EtOH, reflux, 4 h, 83%; ii. POCl3/DMF, 0–5 °C to 120 °C, 1.5 h, 85%; iii. a. KMnO4 H2O, MW, 0.5 h; b. HCl, 95%; iv. SOCl2, reflux, 2 h; v. RNH2, THF, Et3N, r.t., 8 h.
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