Table 1.

Metabolic stability of compounds 7a–7f in mice plasma extract and brain homogenate at 37 °C.

Compound	R	Biological Matrix	Kinetic Constants
			Ke (min−1) (×10−2)	t1/2 (min)
7a		Plasma	31.1	2.23
		Brain	19.9	3.48
7b		Plasma	7.06	9.82
		Brain	6.82	10.17
7c		Plasma	6.77	10.24
		Brain	4.05	17.10
7d		Plasma	4.50	15.41
		Brain	6.34	10.93
7e		Plasma	4.34	15.97
		Brain	3.69	18.78
7f		Plasma	4.48	15.47
		Brain	5.78	11.99