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Pharmacokinetic parameters of LCX001 in plasma after administration of LCX001 and prodrug 7e (n = 3).
| Compound | Cmax (ng/mL) | AUC0-t (h·ng/mL) | Tmax (h) | t1/2 (h) | MRT0-t (h) |
|---|---|---|---|---|---|
| LCX001 | 833.67 ± 79.85 | 951.66 ± 115.52 | 0.08 | 0.53 ± 0.17 | 1.08 ± 0.04 |
| 7e | 590.36 ± 99.90 * | 384.16 ± 39.21 * | 0.08 | 0.48 ± 0.20 | 0.83 ± 0.03 * |
* p < 0.05 with respect to naked LCX001.
