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Pharmacokinetic parameters of LCX001 in brain after administration of LCX001 and prodrug 7e (n = 3).
| Compound | Cmax (ng/g) | AUC0-t (h·ng/g) | Tmax (h) | t1/2 (h) | MRT0-t (h) |
|---|---|---|---|---|---|
| LCX001 | 609.40 ± 73.66 | 504.32 ± 204.71 | 0.08 | 0.59 ± 0.08 | 0.70 ± 0.22 |
| 7e | 454.53 ± 74.69 | 1125.49 ± 336.57 * | 0.17 | 2.50 ± 0.42 * | 2.30 ± 0.73 * |
* p < 0.05 with respect to naked LCX001.
