Table 1.
Food intake, body weight, and organ weights.
| Parameters | STD | HFD | HFD + Orlistat | HFD + 0.2% HT048 | HFD + 0.6% HT048 |
|---|---|---|---|---|---|
| Food intake (g/day) | 17.90 ± 2.69 a | 14.39 ± 2.25 bc | 15.55 ± 3.74 b | 14.15 ± 1.96 c | 14.31 ± 2.32 bc |
| Body weight (g) | |||||
| Initial weight | 114.90 ± 8.05 | 114.93 ± 6.40 | 114.93 ± 9.15 | 114.85 ± 4.44 | 114.88 ± 5.94 |
| Final weight | 444.50 ± 20.64 c | 508.83± 17.04 a | 460.00 ± 32.50 bc | 479.92 ± 29.56 b | 474.75 ± 31.74 b |
| Weight gain | 329.60 ± 22.88 c | 393.91 ± 18.69 a | 345.07 ± 29.17 bc | 365.07 ± 30.92 b | 359.88 ± 31.12 b |
| Organ weight (g) | |||||
| Liver | 10.19 ± 0.83 b | 11.07 ± 0.51 a | 10.46 ± 1.13 ab | 10.02 ± 0.96 b | 9.91 ± 0.70 b |
| Spleen | 0.83 ± 0.09 ab | 0.86 ± 0.16 a | 0.81 ± 0.11 ab | 0.76 ± 0.09 b | 0.75 ± 0.10 b |
| Epididymal | 7.01 ± 1.70 c | 13.15 ± 2.65 a | 9.16 ± 2.58 b | 9.94 ± 1.69 b | 10.11 ± 2.57 b |
| Mesenteric | 2.49 ± 0.66 d | 6.55 ± 1.50 a | 3.86 ± 1.27 c | 5.11 ± 1.09 b | 5.10 ± 1.69 b |
| Perirenal | 5.63 ± 2.04 c | 13.01 ± 3.14 a | 8.63 ± 1.94 b | 10.55 ± 2.36 b | 9.61 ± 2.94 b |
| Total WAT | 15.13 ± 3.83 c | 32.72 ± 5.22 a | 21.65 ± 5.40 b | 25.60 ± 4.00 b | 24.81 ± 5.61 b |
Values are mean ± SD (n = 12 for each group). Data were analyzed by one way-analysis of variance (ANOVA) followed by Duncan’s multiple range test. abc Means not sharing common letters are significantly different among the groups at p < 0.05.