Table 3.
Anti-inflammatory activity of Trillium govanianum rhizome methanol extract and fractions in carrageenan-induced paw edema assay.
| Sample | Dose (mg/kg) | 1st h | 2nd h | 3rd h | 4th h | 5th h |
|---|---|---|---|---|---|---|
| Diclofenac sodium | 10 | 27.3 ± 2.7 *** | 47.6 ± 0.8 *** | 67.0 ± 2.5 *** | 70.6 ± 0.6 *** | 74.3 ± 0.6 *** |
| MeOH-ext | 50 | 8.0 ± 1.7 * | 18.0 ± 1.7 ** | 22.6 ± 2.3 *** | 32.0 ± 5.2 *** | 34.0 ± 5.2 *** |
| 100 | 12.0 ± 1.1 ** | 44.3 ± 4.6 *** | 65.0 ± 4.6 *** | 63.6 ± 1.7 *** | 66.3 + 4.6 *** | |
| 200 | 19.0 ± 2.3 * | 44.6 ± 3.8 *** | 62.6 ± 3.7 *** | 62.6 ± 1.4 *** | 64.6 ± 4.0 *** | |
| Chl-fr | 25 | 4.0 ± 1.0 * | 8.5 ± 0.5 * | 21.3 ± 3.5 ** | 35.0 ± 1.0 *** | 42.5 ± 2.5 *** |
| 50 | 4.0 ± 2.0 ** | 18.8 ± 1.0 ** | 20.3 ± 2.0 ** | 43.0 ± 1.0 *** | 58.0 ± 1.0 *** | |
| 100 | 12.1 ± 3.0 * | 21.5 ± 0.5 ** | 43.5 ± 3.5 *** | 45.0 ± 1.0 *** | 63.5 ± 0.5 *** | |
| EtOAc-fr | 25 | 3.5 ± 0.5 * | 9.5 ± 0.5 * | 18.0 ± 3.0 ** | 18.5 ± 1.5 ** | 39.5 ± 0.5 *** |
| 50 | 10.5 ± 0.5 * | 16.0 ± 1.0 ** | 29.5 ± 0.5 *** | 30.5 ± 2.5 *** | 44.5 ± 3.5 *** | |
| 100 | 9.5 ± 0.5 * | 22.5 ± 1.5 ** | 30.5 ± 0.5 *** | 33.0 ± 2.0 *** | 47.5 ± 0.5 *** | |
| BuOH-fr | 25 | 12.9 ± 3.7 * | 14.3 ± 5.5 * | 35.2 ± 1.0 *** | 58.0 ± 1.5 *** | 61.0 ± 3.4 *** |
| 50 | 18.8 ± 3.4 *** | 46.6 ± 4.9 *** | 68.6 ± 2.3 *** | 66.0 ± 1.7 *** | 69.0 ± 4.3 *** | |
| 100 | 25.6 ± 1.7 *** | 47.6 ± 2.1 *** | 68.6 ± 1.4 *** | 70.3 ± 2.6 *** | 72.6 ± 3.9 *** |
Percent inhibition of paw edema is expressed as mean ± SEM. One-way ANOVA followed by Dunnett’s post hoc test: * p < 0.05, ** p < 0.0, *** p < 0.001 compared to saline control; N = 6 mice per group.