Table 1.
Pharmacokinetic parameters of curcumin following per oral administration of curcumin, curcumin-loaded solid dispersion and its physical mixture.
| Treatment | Curcumin | Physical Mixture | Curcumin-Loaded Solid Dispersion |
|---|---|---|---|
| Dose (mg/kg) | 200 | 30 | 30 |
| Cmax (ng/mL) | 17.9 ± 5.3 | 69.9 ± 18.4 | 233 ± 62.4 |
| Cmax/D (ng/mL/mg/kg) | 0.09 ± 0.03 | 2.33 ± 0.61 * | 7.77 ± 2.08 * |
| Tmax (h) | 0.44 ± 0.13 | 0.50 ± 0.00 | 0.63 ± 0.14 |
| t1/2 (h) | 1.61 ± 0.74 | 3.66 ± 2.16 | 1.93 ± 0.33 |
| AUClast (ng·h/mL) | 19.9 ± 4.77 | 60.5 ± 17.3 | 240 ± 30.2 |
| AUC∞ (ng·h/mL) | 26.8 ± 6.84 | 89.0 ± 43.3 | 262 ± 35.3 |
| AUC∞/D (ng·h/mL/mg/kg) | 0.13 ± 0.03 | 2.97 ± 1.44 * | 8.73 ± 1.18 * |
Data are presented as mean ± S.D., n = 3–4; Cmax, maximum plasma concentration; Tmax, time to reach Cmax; AUC, area under the plasma concentration–time curve; Cmax/D and AUC∞/D, dose normalized Cmax and AUC∞, respectively; t1/2, terminal elimination half-life. * p < 0.05 compared with the curcumin group.