Table 1.
IC50 values of the 1,2,3-triazole compounds 2–5(a–f) for AChE inhibition, DPPH and SOD activities.
| Compound | AChE IC50 (µM) | DPPH IC50 (µg/mL) | SOD IC50 (µg/mL) |
|---|---|---|---|
| 2a | 64.65 (±2.05) | 155.49 (±0.08) | 45.12 (±0.04) |
| 2b | 52.29 (±0.16) | 158.72 (±0.05) | 107.54 (±0.07) |
| 2c | 67.03 (±1.62) | 175.65 (±0.06) | 147.36 (±0.05) |
| 2d | 62.41 (±0.85) | 152.84 (±0.05) | 154.79 (±0.06) |
| 2e | 66.38 (±2.50) | 222.16 (±0.07) | 131.43 (±0.06) |
| 2f | 50.80 (±1.01) | 167.51 (±0.05) | 88.15 (±0.06) |
| 3a | 63.28 (±0.96) | 141.57 (±0.08) | 120.53 (±0.04) |
| 3b | 56.98 (±3.87) | 113.63 (±0.05) | 51.37 (±0.07) |
| 3c | 75.70 (±6.97) | 188.45 (±0.11) | 284.10 (±0.07) |
| 3d | 75.74 (±7.19) | 149.21 (±0.06) | 128.24 (±0.10) |
| 3e | 56.99 (±0.74) | 252.68 (±0.06) | 52.89 (±0.06) |
| 3f | 78.60 (±0.81) | 207.57 (±0.09) | 98.35 (±0.06) |
| 4a | 62.82 (±1.07) | 192.02 (±0.12) | 55.67 (±0.08) |
| 4b | 74.13 (±7.5) | 125.05 (±0.08) | 121.74 (±0.08) |
| 4c | 83.37 (±1.19) | 227.38 (±0.07) | 60.32 (±0.07) |
| 4d | 58.49 (±0.72) | 204.31 (±0.11) | 82.77 (±0.11) |
| 4e | 63.39 (±0.09) | 192.04 (±0.09) | 88.86 (±0.09) |
| 4f | 62.52 (±2.55) | 210.33 (±0.08) | 93.47 (±0.09) |
| 5a | 74.69 (±0.84) | 150.03 (±0.08) | 126.2 (±0.07) |
| 5b | 61.85 (±3.54) | 154.51 (±0.07) | 109.17 (±0.10) |
| 5c | 69.41 (±0.72) | 192.46 (±0.11) | 145.68 (±0.11) |
| 5d | 70.31 (±4.65) | 191.39 (±0.08) | 157.14 (±0.07) |
| 5e | 61.81 (±2.57) | 221.57 (±0.06) | 188.84 (±0.08) |
| Galantamine | 15.09 (±0.01) | - | - |
| BHA | - | 98.56 (±0.08) | - |