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. 2016 Feb 25;21(3):260. doi: 10.3390/molecules21030260

Figure 1.

Figure 1

The effects of CGA ± Cort on the cell growth of fetal rat raphe neurons in vitro. (A) CGA dose response in protection of Cort-induced cell inhibition, CGA 0.001–10 µM and Cort 10 µM; (B) Time response curve of CGA in protection of Cort-induced cell inhibition; ■ Control; ▼CGA 1 nM; ▲ Cort 10 µM; and ● CGA 1 nM + Cort 10 µM; (C) A representative image of control showing normal neurons; (D) A representative image of CGA (1 nM) treatment showing no neurons damage; (E) A representative image of Cort (10 µM) treatment showing Cort-induced neurons damage including cell body atrophy, axon and dendrite loss; (F) A representative image of co-treatment of CGA (1 nM) and Cort (10 µM) showing prevention of Cort-induced neurons damage by CGA. The control cells were treated with culture medium with 0.1% DMSO. The results are representative of at least three independent experiments run in triplicate and expressed as the mean ± SD. ** p < 0.01 vs. Cort treatment.