Table 1.
Cytotoxicity parameters of some naturally occurring hydroxyphenylalkanes and diarylheptanoids against different solid tumor cell lines.
| Compound | HCT-116 | HepG2 | MCF-7 | HeLa | ||||
|---|---|---|---|---|---|---|---|---|
| IC50 (µM) | R-Value (%) | IC50 (µM) | R-Value (%) | IC50 (µM) | R-Value (%) | IC50 (µM) | R-Value (%) | |
| 6-Paradol (1) | 10.4 | 15.1 | >100 | N/A | 20.4 | 42.9 | 57.7 | 37.9 |
| 6-Gingerol (2) | 1.5 | 60.6 | 71.9 | N/A | >100 | 85.6 | 15.5 | 43.8 |
| Dehydrogingerdione (3) | 12.6 | N/A | >100 | N/A | 63.7 | N/A | 55.8 | 1.1 |
| 6-Shogoal (4) | 3.1 | N/A | 18.7 | N/A | 7.5 | 1.1 | 10.2 | 1.1 |
| 4′-Methoxy-6-gingerol (5) | 11.4 | 4.6 | 19.4 | N/A | 12.0 | N/A | 9.2 | 0.5 |
| Dihydro-6-paradol (6) | 12.0 | N/A | 13.5 | 50.2 | 63.5 | 42.9 | 14.7 | 0.9 |
| DIACHEP (7) | 11.2 | 4.1 | >100 | N/A | 61.5 | N/A | 20.2 | 0.94 |
| Dihydrogingerenone-C (8) | 10.5 | 10.7 | N/A | 75.5 | 20.4 | 65.5 | 16.6 | 15.1 |
| Dihydrogingerenone-A (9) | 12.2 | 7.8 | N/A | N/A | 59.4 | 0.7 | 17.5 | 5.5 |