Table 2.

Studies employed the Citrus flavones and their experimental models of neurodegeneration.

Flavones	Model	Disease/Condition	Reference
apigenin	In vitro	HT22 cells	Choi et al., 2010 [87]
	In vitro	QUIN-treated primary human neuron	Braidy et al., 2010 [88]
	In vitro	glutamate-treated cerebellar and cortical neurons	Losi et al., 2004 [89]
	In vivo	APP/PS1 double transgenic mouse	Zhao et al., 2013 [90]
	In vivo	Aβ25–35-treated mouse	Liu et al., 2011 [91]
	In vivo	young male Wistar rats	Popovic et al., 2014 [92]
	In vivo	7-week old mice	Taupin et al., 2009 [93]
	In vivo	MPTP-treated mice	Patil et al., 2014 [95]
	In vitro	MPP+-incubated PC12 cells	Liu et al., 2015 [96]
	In vitro	4-HNE-exposed PC12 cells	Wu et al., 2015 [97]
	In vivo	aged and LPS-intoxicated mice	Patil et al., 2003 [94]
luteolin	In vivo	chronic cerebral hypoperfusion in rats	Fu et al., 2014 [98]
	In vivo	chronic cerebral hypoperfusion in rats	Xu et al., 2010 [99]
	In vivo	obesity mice	Liu et al., 2014 [100]
	In vivo	ICV-STZ injected rat	Wang et al., 2016 [101]
	In vitro	6-OHDA-exposed PC12 cells	Hu et al., 2014 [102]
	In vivo	MPTP-treated mice	Patil et al., 2014 [95]
	In vitro	MPP+-exposed PC12 and glial C6 cells	Wruck et al., 2007 [103]
	In vitro	IFN-γ-incubated N9 and microglia cells	Rezai-Zadeh et al., 2008 [104]
	In vitro	N2a cells transfected with SweAPP	Rezai-Zadeh et al., 2009 [105]
	In vitro	LPS/IFN-γ-treated rat primary microglia and BV-2 microglial cells	Kao et al., 2011 [106]
	In vitro	LPS-incubated microglia cells	Chen et al., 2008 [107]
	In vitro	LPS-exposed BV2 microglia	Zhu et al., 2011 [108]
	In vitro	SH-SY5Y cells co-cultured with LPS-stimulated BV2 microglia	Zhu et al., 2014 [109]
	In vitro	LPS-treated microglia cells	Dirscherl et al., 2010 [110]