Table 5.

Studies and experimental models of neurodegenerative diseases in which tangeretin or nobiletin were used.

Polymethoxyflavones	Model	Disease/Condition	Reference
tangeretin	In vivo	6-OHDA-injected rat	Datla et al., 2001 [155]
	In vitro	LPS-stimulated microglia and BV-2 cells	Shu et al., 2014 [156]
nobiletin	In vitro	Aβ1–42 or Aβ1–40-exposed hippocampus neurons of rats	Matzukazi et al., 2006 [157]
	In vivo	Aβ1–40-treated rats
	In vivo	APP-SL 7-5 mice	Onozuka et al., 2008 [158]
	In vivo	SAMP8 mice	Nakajima et al., 2013 [159]
	In vivo	3XTg-AD mice	Nakajima et al., 2015 [160]
	In vivo	transgenic mice	Yamakuni et al., 2010 [161]
	In vivo	MPP+- injected mice	Jeong et al., 2014 [162]
	In vitro	LPS-treated BV-2 microglia cell	Cui et al., 2010 [163]
	In vivo	cerebral ischemia inducted mice	Yamamoto et al., 2009 [164]
	In vivo	cerebral ischemia inducted rats	Zhang et al., 2016 [165]