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. 2016 Jun 22;21(6):817. doi: 10.3390/molecules21060817

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Reaction sequence for the preparation of HYNIC-D₁-FA₂ and radiolabeling procedure of ^99mTc-HYNIC-D₁-FA₂. In our study, the novel folate derivative is composed of four structural components: targeting moiety FA, PAMAM (D₁), 1,2,3-triazole linkage, and bifunctional chelator.