Table 1.

BACE-1 inhibitory potency of the new compounds 3–7 and reference compound (inhibitor IV).

Compound	R	hBACE-1 Inhibition IC50 (μM) a
3		3.18 ± 0.21
4		1.06 ± 0.15
5		4.02 ± 0.29
6		1.56 ± 0.23
7		3.97 ± 0.33
Inhibitor IV b		0.02 ± 0.00

^a All data were obtained at least in triplicate, and the values listed are the average from multiple experiments, each performed in triplicate. SEM ± standard error of the mean; ^b See ref [22].