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. 2016 Oct 14;21(10):1364. doi: 10.3390/molecules21101364

Figure 3.

Figure 3

Solasonine possesses selectivity for inhibiting Hh pathway activity. (A) Solasonine had no effect on the NF-κB activity. The 293T cells transfected with luciferase reporter plasmids with NF-κB binding sites and TK-Renilla plasmids were treated with TNF-α with or without BAY 11-872 or solasonine for 24 h. The results are expressed as mean ± s.d. (n = 3); (B) Solasonine had no effect on the TCF/LEF activity. The LS174T cells were transfected with luciferase reporter constructs with TCF/LEF binding sites and the TK-Renilla plasmids, and subjected to PGE2 with various concentrations of solasonine or H89 for 24 h. The results are expressed as mean ± s.d. (n = 3). Statistical differences were analyzed by the two-tailed Student′s t test and p < 0.05 was considered as significant # p > 0.05.