Table 2.
Antimicrobial activity as MICs (µM) of fluconazole and synthesized compounds against tested microorganisms and selectivity index (SI) of the synthesized compounds.
| Comp. | Invasive Fungi | Dermatophytic Fungi | PC3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CaR | Ca | Ct | Cp | Af | An | Tm | Mc | IC50 | |
| 6a | 1.57 | 1.57 | 1.57 | 1.57 | 1.57 | 1.57 | 3.14 | 1.57 | 38.86 |
| (24.75) | (24.75) | (24.75) | (24.75) | (24.75) | (24.75) | (12.38) | (24.75) | ||
| 8a | 0.81 | 0.20 | 0.41 | 0.20 | NA | NA | NA | NA | 37.36 |
| (46.12) | (>100) | (91.12) | (>100) | ||||||
| 10a | NA | 1.57 | 1.57 | 1.57 | 1.57 | 3.14 | 1.57 | 1.57 | 35.14 |
| (22.38) | (22.38) | (22.38) | (22.38) | (11.19) | (22.38) | (22.38) | |||
| 10b | 0.19 | 0.19 | 0.19 | 0.19 | NA | NA | NA | NA | 37.09 |
| (>100) | (>100) | (>100) | (>100) | ||||||
| 10e | NA | NA | NA | NA | 0.16 | 0.66 | 0.66 | 0.66 | 38.73 |
| (>100) | (58.68) | (58.68) | (58.68) | ||||||
| 12a | NA | NA | NA | NA | 0.20 | 0.79 | 0.79 | 0.20 | 28.90 |
| (>100) | (36.6) | (36.60) | (>100) | ||||||
| Fluconazole | NA | 1 | 1 | 1 | 2.6 | 2 | 2 | 2 | |