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. 2016 Dec 21;21(12):1757. doi: 10.3390/molecules21121757

Figure 3.

Figure 3

Effects of riparins on rota-rod and tail flick tests in mice. Panel (A) shows the effects of riparins I, II, III and IV (100 mg/kg) on motor function in mice. Bar graphs representing the run time on the rota-rod, 40 min after the intraperitoneal administration of riparins I–IV (100 mg/kg), vehicle (Veh; Tween 80 5%; control group) or diazepam (DZP; 10 mg/kg, reference drug); Panel (B) shows tail flick test data represented as Antinociception Index. The thermal nociceptive threshold was evaluated before (B) and up to 120 min following intraperitoneal administration of riparin IV (25 mg/kg), vehicle (Veh: Tween 80.5%; control group) or morphine (Mor: 5 mg/kg; reference drug). All data are reported as means ± SEM; n = 6 mice per group. *** Significantly different from control group (p < 0.001) as determined by ANOVA followed by Tukey’s test (Panel A) or Two-way ANOVA followed by Bonferroni’s test (B).