TABLE 2. Seizure outcomes stratified by factors of interest.
| Factor | Completely Seizure Free | Persistent Seizures | p Value | Drop Attack Free | Persistent Drop Attacks | p Value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age at op (yrs) | 15.4 ± 2.6 | 16.6 ± 1.2 | 0.402 | 16.0 ± 2.3 | 15.7 ± 2.0 | 0.851 |
| Sex | ||||||
| Female | 17 (19.1%) | 72 (80.9%) | 0.290 | 32 (60.4%) | 21 (39.6%) | 0.700 |
| Male | 20 (13.9%) | 124 (86.1%) | 41 (56.9%) | 31 (43.1%) | ||
| Surgery & diagnostics | ||||||
| Callosotomy extent | ||||||
| Partial | 63 (14.3%) | 377 (85.7%) | 0.030* | 83 (42.6%) | 112 (57.4%) | 0.002* |
| Complete | 34 (21.8%) | 122 (78.2%) | 50 (63.3%) | 29 (36.7%) | ||
| MRI findings | ||||||
| Normal | 19 (36.5%) | 33 (63.5%) | 0.018* | 26 (65.0%) | 14 (35.0%) | 0.117 |
| Abnormal | 17 (18.7%) | 74 (81.3%) | 42 (50.0%) | 42 (50.0%) | ||
| EEG findings | ||||||
| Lateralized | 3 (7.3%) | 38 (92.7%) | 0.020* | 5 (35.7%) | 9 (64.3%) | 0.155 |
| Nonlateralized | 41 (23.6%) | 133 (76.4%) | 68 (55.7%) | 54 (44.3%) | ||
| Disease characteristics | ||||||
| Seizure frequency (monthly) | 258.4 ± 170.0 | 181.7 ± 46.8 | 0.242 | 165.2 ± 54.4 | 248.0 ± 80.3 | 0.096 |
| Epilepsy duration | ||||||
| <15 yrs | 48 (27.4%) | 127 (72.6%) | 0.014* | 52 (52.0%) | 48 (48.0%) | 0.687 |
| ≥15 yrs | 13 (14.1%) | 79 (85.9%) | 31 (55.4%) | 25 (44.6%) | ||
| Generalized seizures | ||||||
| Present | 47 (15.2%) | 263 (84.8%) | 0.873 | 73 (54.5%) | 61 (45.5%) | 0.364 |
| Absent | 12 (14.5%) | 71 (85.5%) | 21 (46.7%) | 24 (53.3%) | ||
| Focal seizures | ||||||
| Present | 23 (13.2%) | 151 (86.8%) | 0.393 | 36 (52.9%) | 32 (47.1%) | 0.325 |
| Absent | 26 (16.6%) | 131 (83.4%) | 34 (44.7%) | 42 (55.3%) | ||
| Infantile spasms | ||||||
| Present | 15 (60.0%) | 10 (40.0%) | <0.001* | 9 (75.0%) | 3 (25.0%) | 0.417 |
| Absent | 12 (16.0%) | 63 (84.0%) | 23 (62.2%) | 14 (37.8%) | ||
| Absence seizures | ||||||
| Present | 8 (11.6%) | 61 (88.4%) | 0.337 | 19 (50.0%) | 19 (50.0%) | 0.711 |
| Absent | 29 (16.5%) | 147 (83.5%) | 53 (53.5%) | 46 (46.5%) | ||
| Epilepsy etiology | ||||||
| Idiopathic | 23 (25.8%) | 66 (74.2%) | 0.085 | 37 (59.7%) | 25 (40.3%) | 0.041* |
| Known | 24 (16.6%) | 121 (83.4%) | 45 (43.3%) | 59 (56.7%) | ||
| Total | 231 (19.0%) | 982 (81.0%) | 373 (55.3%) | 302 (44.7%) | ||
Data are expressed as the mean ± 95% CI for continuous variables and number (%) for categorical variables.
*
p < 0.05, t-test for continuous variables or chi-square test for categorical variables.