Table 1.

Obstetric outcome after lithium treatment during pregnancy: findings from clinical cohort studies

Study	Design	Sample size	Findings
Petersen et al. (2016)	Registry-based study	Exposed = 35 Disease matched non-exposed = 84 Controls = 320.853	No difference in the rate of caesarean sections
Frayne et al. (2017)	Cohort study	Exposed = 33	No difference in the rate of obstetric complications between the women that continued (n = 19) or discontinued (n = 14) lithium
Munk-Olsen et al. (2018)	Meta-analysis (six study sites)	Exposed = 727 Disease matched controls = 21,397	No association between lithium exposure in utero and preeclampsia (OR 0.97, 95% CI 0.52–1.80), gestational diabetes (OR 1.20, 95% CI 0.81–1.78), fetal distress (OR 1.00, 95% CI 0.76–1.32), postpartum hemorrhage (OR 1.28, 95% CI 0.64–2.57) and caesarean section (OR 0.94, 95% CI 0.66–1.33)

OR odds ratio, CI confidence interval