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. 2018 Nov 21;19(11):3685. doi: 10.3390/ijms19113685
ADA anti-drug antibodies
ADC antibody drug conjugate
ADCC antibody-dependent cell-mediated
ADEPT antibody-directed enzyme prodrug therapy
CCR complex chromosomal rearrangement
CD cluster of differentiation, which identifies cell surface molecules
CRS cytokine release syndrome
CTLA-4 cytotoxic T-lymphocyte antigen 4
EGFR epidermal growth factor receptor
Fab fragment antigen binding
Fc fragment constant
FIH First-in-human
IC immune complex
IgG immunoglobulin G
IHC Immunohistochemistry
mAb monoclonal antibody
MABEL minimal anticipated biological effect level
MRSD maximum recommended starting dose
NOAEL no observable adverse effect level
PD-1 programmed cell death-1
PK/PD pharmacokinetic/pharmacodynamic
scFv single chain variable fragments
TCR tissue cross-reactivity
TNF tumor necrosis factor
USFDA United States Food and Drug Administration
VEGF vascular endothelial growth factor