ADA |
anti-drug antibodies |
ADC |
antibody drug conjugate |
ADCC |
antibody-dependent cell-mediated |
ADEPT |
antibody-directed enzyme prodrug therapy |
CCR |
complex chromosomal rearrangement |
CD |
cluster of differentiation, which identifies cell surface molecules |
CRS |
cytokine release syndrome |
CTLA-4 |
cytotoxic T-lymphocyte antigen 4 |
EGFR |
epidermal growth factor receptor |
Fab |
fragment antigen binding |
Fc |
fragment constant |
FIH |
First-in-human |
IC |
immune complex |
IgG |
immunoglobulin G |
IHC |
Immunohistochemistry |
mAb |
monoclonal antibody |
MABEL |
minimal anticipated biological effect level |
MRSD |
maximum recommended starting dose |
NOAEL |
no observable adverse effect level |
PD-1 |
programmed cell death-1 |
PK/PD |
pharmacokinetic/pharmacodynamic |
scFv |
single chain variable fragments |
TCR |
tissue cross-reactivity |
TNF |
tumor necrosis factor |
USFDA |
United States Food and Drug Administration |
VEGF |
vascular endothelial growth factor |