Clinical variables from Conners’ Parents Rating Scale-Revised (CPRS-R) and human endogenous retrovirus H (HERV-H) expression. (A) Mean values ± standard deviations (SD) of the four clinical variables (Conners’ parent oppositional, Conners’ parent inattention, Conners’ parent hyperactivity/impulsivity, and Conners’ parent ADHD-Index) in seven ADHD patients before the beginning of MPH therapy and after eight and 24 weeks. The dashed line represents the cut-off score. Single asterisk (*) indicates p values < 0.05 and double (**) indicates p values < 0.001. (B) HERV-H relative expression evaluated by real-time RT-PCR analysis plotted against the clinical variables. The patients are represented according to the time points by different colors: black for patients at the beginning of therapy, grey for patients analyzed after eight weeks of therapy, and white for patients after 24 weeks of therapy. Rho and p values for Spearman correlation analysis are shown.