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. 2018 Nov 19;19(11):3645. doi: 10.3390/ijms19113645

Figure 2.

Figure 2

Concentration-dependent effects of local administration of MK801 into the mPFC and mediodorsal thalamic nucleus (MDTN) on L-glutamate release in the mPFC. (A) indicates the comparison of the concentration-dependent effect of perfusion with MK801 (25 and 50 μM) into the MDTN and mPFC on L-glutamate release in the mPFC. In (A), ordinate: mean ± SD (n = 6) of the extracellular L-glutamate level in the mPFC (μM), abscissa: time after administration of MK801 (min). Open bars: perfusion of MK801. (B) indicates mean ± SD (n = 6) of AUC value of the extracellular L-glutamate level in mPFC (μM) during perfusion with MK801 (25 and 50 μM) into the MDTN (gray columns) and into the mPFC (opened columns) from 0 to 180 min of (A). * p < 0.05, ** p < 0.01; relative to control (MRS alone) using LMM with Tukey’s post hoc test.