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. 2018 Nov 19;19(11):3645. doi: 10.3390/ijms19113645

Figure 3.

Figure 3

Effects of local administration of agonists of cystine/glutamate antiporter (Sxc), metabotropic glutamate receptors (mGluR), and GABAA receptors into the MDTN on systemic MK801-evoked L-glutamate release in the mPFC. (A,B) indicate the effects of perfusion with L-AP4 (30 and 100 μM), muscimol (MUS) (1 μM) [5,6], NAC (0.5 and 1 mM), and LY354740 (30 and 100 μM) into the MDTN (black bars) on systemic MK801-evoked L-glutamate release in the mPFC, compared with MK801 alone (1 mg/kg, i.p.) from (A). Ordinates: mean ± SD (n = 6) of the extracellular L-glutamate level in the mPFC (μM), abscissa: time after administration of 1 mg/kg MK801 (min). Black arrows indicate the intraperitoneal injection of MK801. Microdialysis was conducted to measure the L-glutamate release in the mPFC. (C) indicates the AUC value of the extracellular L-glutamate level in the mPFC (μM) after MK801 injection from 0 to 180 min of (A,B). ** P < 0.01; relative to 1 mg/kg MK801 alone (control) using LMM with Tukey’s post hoc test.