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. 2018 Nov 19;19(11):3645. doi: 10.3390/ijms19113645

Figure 8.

Figure 8

Our proposed hypothesis for the extended neural circuitry involved in MK801-induced L-glutamate release in the mPFC. MK801 inhibits tonically-active NMDAR (red squares) on MDTN GABAergic neurons (blue hexagon), which project to MDTN glutamatergic neurons (red circle). Inhibition of NMDAR in MDTN GABAergic neurons leads to disinhibition of MDTN glutamatergic neurons. This disinhibition results in the enhancement of MDTN glutamatergic signaling (increased L-glutamate release in the mPFC). II-mGluRs (green wave) in both the MDTN and mPFC are activated by glial-released L-glutamate through astroglial Sxc (gray ellipse). Activation of extra-synaptic II-mGluRs in the MDTN and mPFC results in the inhibition of MDTN glutamatergic projection. Activated III-mGluR (blown wave) in the mPFC pre-synaptically inhibits the activity of MDTN glutamatergic projection. APZ probably compensates hyper-activation of thalamo-cortical glutamatergic transmission via the activation of II-mGluR in both MDTN and mPFC.