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The flowchart of PWCDA is illustrated by five main steps. Step 1: Calculate circRNA semantic similarity and disease similarity scores, respectively. Step 2: Calculate GIP Kernel similarity scores for circRNAs and diseases. Step 3: Integrate circRNA (disease) semantic (functional) similarity with circRNA/disease GIP Kernel similarity, respectively. Step 4: Construct the heterogeneous network. Step 5: Calculate an association score for each circRNA-disease pair.
