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(A) Schematic representation of the consequences of the activation of innate signalling mechanisms in airway epithelial cells by group 1 HDM allergens. Please refer to text for full description of how the protease-initiated release of epithelial mediators coordinates a response of effector cells implicated in the initiation and progression of allergy. (B) Effects of allergen delivery inhibitor (ADI) compounds on the events depicted in (A) with inhibited pathways dimmed out.
