Table 7.
The mean gene fold changes underlying the cAMP pathway in Pgc-1α−/− compared to WT atria.
| Gene | Protein | Mean WT Fold Change (n = 3) | WT SE | Mean Pgc-1α−/− Fold Change (n = 3) | Pgc-1α−/− SE | t-Test (Unpaired) p Value |
|---|---|---|---|---|---|---|
| Adcy4 | Adenylyl cyclase type 4 | 1.00 | 0.08 | 0.64 | 0.05 | 0.017 |
| Adcy5 | Adenylyl cyclase type 5 | 1.00 | 0.38 | 0.83 | 0.15 | 0.706 |
| Pde2a | cGMP-dependent 3′,5′-cyclic phosphodiesterase 2A | 1.00 | 0.08 | 1.12 | 0.11 | 0.429 |
| Pde4d | cAMP-specific 3′,5′-cyclic phosphodiesterase 4D | 1.00 | 0.15 | 1.29 | 0.12 | 0.209 |
| Prkaca | Catalytic subunit α of protein kinase A | 1.00 | 0.14 | 0.85 | 0.09 | 0.394 |
| Prkar1a | cAMP-dependent protein kinase type I-α regulatory subunit | 1.00 | 0.11 | 1.47 | 0.14 | 0.061 |
| Prkar2a | cAMP-dependent protein kinase type II-α regulatory subunit | 1.00 | 0.05 | 0.81 | 0.10 | 0.161 |
| Prkar2b | cAMP-dependent protein kinase type II-β regulatory subunit | 1.00 | 0.37 | 1.78 | 0.37 | 0.212 |
| Camk2d | Calcium/calmodulin-dependent protein kinase type II delta | 1.00 | 0.07 | 1.09 | 0.14 | 0.585 |