Table 9.
Stratifications of mean gene fold changes in Pgc-1α−/− compared to WT atria.
| (A) Mean Gene Fold Changes in Pgc-1α−/− Compared to WT Atria in Ascending Order of p Value up to p ≤ 0.1. | ||||||
| Gene | Protein | Mean WT Fold Change (n = 3) | WT SE | Mean Pgc-1α−/− Fold Change (n = 3) | Pgc-1α−/− SE | t-Test (Unpaired) p Value |
| Tbx3 | T-box transcription factor | 1.00 | 0.00 | 0.69 | 0.02 | 0.000 |
| Cacna2d2 | Ca2+ channel, voltage-dependent, α2/δ2 subunit | 1.00 | 0.05 | 0.50 | 0.07 | 0.005 |
| Scn5a | Na+ voltage-gated channel type 5 subunit α, Nav1.5 | 1.00 | 0.11 | 0.52 | 0.04 | 0.012 |
| Adcy4 | Adenylyl cyclase type 4 | 1.00 | 0.08 | 0.64 | 0.05 | 0.017 |
| Hcn1 | Hyperpolarisation activated cyclic nucleotide-gated channel 1 | 1.00 | 0.07 | 0.50 | 0.12 | 0.022 |
| Atp1b1 | Na-K-transporting ATPase subunit β1 | 1.00 | 0.17 | 0.42 | 0.04 | 0.028 |
| Adra1d | α-1D adrenoreceptor | 1.00 | 0.24 | 0.19 | 0.08 | 0.035 |
| Casq2 | Calsequestrin 2 | 1.00 | 0.08 | 0.72 | 0.06 | 0.050 |
| Cacna1c | Ca2+ channel, voltage-dependent, L type, α1C subunit (Cav1.2) | 1.00 | 0.09 | 0.65 | 0.09 | 0.051 |
| Prkar1a | cAMP-dependent protein kinase type I-α regulatory subunit | 1.00 | 0.11 | 1.47 | 0.14 | 0.061 |
| Atp1a2 | Na-K-transporting ATPase subunit α2 | 1.00 | 0.12 | 0.46 | 0.17 | 0.062 |
| Atp1a1 | Na-K-transporting ATPase subunit α1 | 1.00 | 0.14 | 0.59 | 0.08 | 0.063 |
| Cacna2d1 | Ca2+ channel, voltage-dependent, α2/δ1 subunit | 1.00 | 0.13 | 0.66 | 0.04 | 0.065 |
| Abcc9 | ATP-binding cassette (ABC) transporter subunit of ATP-sensitive K+ channels | 1.00 | 0.11 | 1.65 | 0.24 | 0.071 |
| Abcc8 | ATP-binding cassette (ABC) transporter subunit of ATP-sensitive K+ channels | 1.00 | 0.12 | 1.77 | 0.30 | 0.078 |
| Scn7a | Na+ voltage-gated channel type 7 subunit α, Nav2.1 | 1.00 | 0.25 | 0.39 | 0.09 | 0.081 |
| Kcnn2 | intermediate/small K+ conductance Ca2+-activated channel, subfamily N, member 2 (KCa2.2) | 1.00 | 0.30 | 0.33 | 0.03 | 0.090 |
| Hcn4 | Hyperpolarisation activated cyclic nucleotide-gated channel 4 | 1.00 | 0.09 | 0.46 | 0.24 | 0.100 |
| (B) Mean Gene Fold Changes in Pgc-1α−/− Compared to WT Atria Ordered by Size of Fold Change for Changes with p ≤ 0.1 | ||||||
| Gene | Protein | Mean WT Fold Change (n = 3) | WT SE | Mean Pgc-1α−/− Fold Change (n = 3) | Pgc-1α−/− SE | t-Test (Unpaired) p Value |
| Downregulated | ||||||
| Adra1d | α-1D adrenoreceptor | 1.00 | 0.24 | 0.19 | 0.08 | 0.035 |
| Kcnn2 | intermediate/small K+ conductance Ca2+-activated channel, subfamily N, member 2 (KCa2.2) | 1.00 | 0.30 | 0.33 | 0.03 | 0.090 |
| Scn7a | Na+ voltage-gated channel type 7 subunit α, Nav2.1 | 1.00 | 0.25 | 0.39 | 0.09 | 0.081 |
| Atp1b1 | Na-K-transporting ATPase subunit β1 | 1.00 | 0.17 | 0.42 | 0.04 | 0.028 |
| Hcn4 | Hyperpolarisation activated cyclic nucleotide-gated channel 4 | 1.00 | 0.09 | 0.46 | 0.24 | 0.100 |
| Atp1a2 | Na-K-transporting ATPase subunit α2 | 1.00 | 0.12 | 0.46 | 0.17 | 0.062 |
| Cacna2d2 | Ca2+ channel, voltage-dependent, α2/δ2 subunit | 1.00 | 0.05 | 0.50 | 0.07 | 0.005 |
| Hcn1 | Hyperpolarisation activated cyclic nucleotide-gated channel 1 | 1.00 | 0.07 | 0.50 | 0.12 | 0.022 |
| Scn5a | Na+ voltage-gated channel type 5 subunit α, Nav1.5 | 1.00 | 0.11 | 0.52 | 0.04 | 0.012 |
| Atp1a1 | Na-K-transporting ATPase subunit α1 | 1.00 | 0.14 | 0.59 | 0.08 | 0.063 |
| Adcy4 | Adenylyl cyclase type 4 | 1.00 | 0.08 | 0.64 | 0.05 | 0.017 |
| Cacna1c | Ca2+ channel, voltage-dependent, L type, α1C subunit (Cav1.2) | 1.00 | 0.09 | 0.65 | 0.09 | 0.051 |
| Cacna2d1 | Ca2+ channel, voltage-dependent, α2/δ1 subunit | 1.00 | 0.13 | 0.66 | 0.04 | 0.065 |
| Tbx3 | T-box transcription factor | 1.00 | 0.00 | 0.69 | 0.02 | 0.000 |
| Casq2 | Calsequestrin 2 | 1.00 | 0.08 | 0.72 | 0.06 | 0.050 |
| Upregulated | ||||||
| Abcc8 | ATP-binding cassette (ABC) transporter subunit of ATP-sensitive K+ channels | 1.00 | 0.12 | 1.77 | 0.30 | 0.078 |
| Abcc9 | ATP-binding cassette (ABC) transporter subunit of ATP-sensitive K+ channels | 1.00 | 0.11 | 1.65 | 0.24 | 0.071 |
| Prkar1a | cAMP-dependent protein kinase type I-α regulatory subunit | 1.00 | 0.11 | 1.47 | 0.14 | 0.061 |