Table 1.
Top 15 up-regulated and down-regulated genes after treatment of human T lymphocytes with 2 µM B[α]P for 48 h.
| ID | Gene Name | Description | Differential Expression (log-2) a | p-Value |
|---|---|---|---|---|
| Top 15 up-regulated genes | ||||
| 1543 | CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.152 | 5.9 × 10−3 |
| 1545 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 1.058 | 4.7 × 10−3 |
| 2706 | GJB2 | gap junction protein, beta 2, 26 kDa | 0.702 | 5.7 × 10−3 |
| 10804 | GJB6 | gap junction protein, beta 6, 30 kDa | 0.528 | 7.7 × 10−3 |
| 25976 | TIPARP | TCDD-inducible poly (ADP-ribose) polymerase | 0.528 | 1.0 × 10−2 |
| 153339 | TMEM167A | transmembrane protein 167A | 0.491 | 3.0 × 10−2 |
| 167826 | OLIG3 | oligodendrocyte transcription factor 3 | 0.484 | 2.7 × 10−2 |
| 91768 | CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.426 | 3.1 × 10−4 |
| 3815 | KIT | proto-oncogene c-Kit | 0.401 | 1.2 × 10−5 |
| 51676 | ASB2 | ankyrin repeat and SOCS box containing 2 | 0.388 | 5.6 × 10−4 |
| 83888 | FGFBP2 | fibroblast growth factor binding protein 2 | 0.362 | 2.0 × 10-3 |
| 5774 | PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.349 | 1.1 × 10−2 |
| 9289 | ADGRG1 | adhesion G protein-coupled receptor G1 | 0.346 | 5.8 × 10-3 |
| 23682 | RAB38 | RAB38, member RAS oncogene family | 0.328 | 4.6 × 10−3 |
| 81618 | ITM2C | integral membrane protein 2C | 0.307 | 1.5 × 10−2 |
| Top 15 down-regulated genes | ||||
| 10964 | IFI44L | interferon-induced protein 44-like | −0.451 | 1.7 × 10−2 |
| 1293 | COL6A3 | collagen, type VI, alpha 3 | −0.337 | 6.3 × 10−3 |
| 10561 | IFI44 | interferon-induced protein 44 | −0.322 | 3.2 × 10−2 |
| 79648 | MCPH1 | microcephalin 1 | −0.319 | 1.0 × 10−2 |
| 1130 | LYST | lysosomal trafficking regulator | −0.282 | 2.2 × 10−2 |
| 4599 | MX1 | MX dynamin-like GTPase 1 | −0.282 | 4.8 × 10−2 |
| 8638 | OASL | 2′-5′-oligoadenylate synthetase- | −0.269 | 2.0 × 10−3 |
| 3433 | IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | −0.267 | 5.6 × 10−4 |
| 10216 | PRG4 | proteoglycan 4 | −0.266 | 3.4 × 10−2 |
| 7070 | THY1 | Thy-1 cell surface antigen | −0.265 | 1.0 × 10−2 |
| 6402 | SELL | selectin L | −0.233 | 3.1 × 10−2 |
| 56479 | KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | −0.232 | 1.7 × 10−2 |
| 1803 | DPP4 | dipeptidyl-peptidase 4 | −0.222 | 2.3 × 10−2 |
| 3394 | IRF8 | interferon regulatory factor 8 | −0.220 | 1.2 × 10−2 |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | −0.207 | 2.1 × 10−2 |
a Differential expression (log-2) corresponds to the difference in mRNA expression measured in log-2 intensities between B[α]P and DMSO (CTR) conditions; they are the medians of 4 microarray experiments, performed on pools of RNAs isolated from CTR or B[α]P-treated primary cultures of T lymphocytes established from 16 blood donors (4 different blood donors per pool).