Table 2.
Top canonical pathways regulated after treatment of human T lymphocytes with 2 µM B[α]P for 48 h.
| Top Pathways | ap-Value | b Regulated Genes |
|---|---|---|
| Up-regulated genes | ||
| Aryl Hydrocarbon Receptor Signaling | 3.99 × 10−5 | AhRR, CCNE2, CDKN1A, CYP1A1, CYP1B1, NQO1 |
| Protein Kinase A Signaling | 7.36 × 10−5 | ADCY9, ADD2, DUSP4, MYH10, MYL9, PPP1R14C, PTPDC1, PTPN3, SAMD3 |
| Estrogen-mediated S-phase entry | 2.06 × 10−4 | CCNE2, CDKN1A, E2F7 |
| Cell cycle: G1/S checkpoint regulation | 2.14 × 10−4 | CCNE2, CDKN1A, E2F7, SAMD3 |
| Down-regulated genes | ||
| Interferon Signaling | 1.41 × 10−4 | IFIT3, MX1, OAS1 |
| Granulocyte Adhesion and Diapedesis | 1.74 × 10−4 | CCL3, CCL3L3, CCL4L1, CCL4L2, SELL, THY1 |
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 5.97 × 10−4 | DDX58, IFIH1, OAS1, OSM |
| Activation of IRF by Cytosolic Pattern Recognition Receptors | 7.42 × 10−4 | DDX58, IFIH1, IFIT2 |
ap-values were calculated using the IPA software. b The list of genes whose expression was altered by B[α]P treatment was given for each pathway by the IPA software.