Table 3.
Top diseases and biological functions regulated after treatment of human T lymphocytes with 2 µM B[α]P for 48 h.
| Network | Top Functions | p-Value a | Focus Genes b |
|---|---|---|---|
| Diseases and Disorders | |||
| 1 | Cancer | 1.82 × 10−3–1.61 × 10−12 | 144 |
| 2 | Hematological Disease | 1.64 × 10−3–1.61 × 10−12 | 67 |
| 3 | Immunological Disease | 1.64 × 10−3–1.61 × 10−12 | 73 |
| 4 | Organismal Injury and Abnormalities | 1.82 × 10−3–1.61 × 10−12 | 147 |
| 5 | Antimicrobial Response | 2.89 × 10−4–2.23 × 10−10 | 19 |
| Molecular and Cellular functions | |||
| 1 | Cellular Movement | 1.77 × 10−3–6.81 × 10−12 | 60 |
| 2 | Cell Death and Survival | 1.59 × 10−3–2.05 × 10−11 | 77 |
| 3 | Cellular Function and Maintenance | 1.30 × 10−3–7.97 × 10−11 | 52 |
| 4 | Cell-To-Cell Signaling and Interaction | 1.82 × 10−3–4.36 × 10−8 | 41 |
| 5 | Cellular Growth and Proliferation | 1.68 × 10−3–5.20 × 10−8 | 77 |
| Physiological system development and function | |||
| 1 | Immune Cell Trafficking | 1.82 × 10−3–6.81 × 10−12 | 45 |
| 2 | Hematological System Development and Function | 1.82 × 10−3–5.20 × 10−10 | 64 |
| 3 | Tissue Morphology | 1.67 × 10−3–2.55 × 10−9 | 56 |
| 4 | Digestive System Development and Function | 1.07 × 10−3–1.75 × 10−7 | 25 |
| 5 | Lymphoid Tissue Structure and Development | 1.78 × 10−3–1.75 × 10−7 | 48 |
ap-values were calculated using the IPA software. b The number of genes whose expression was altered by B[α]P treatment was given for each diseases and functions by the IPA software.