Table 1.

Revised Japanese criteria for Sjögren syndrome (SS) (1999).

Revised Japanese Criteria for Sjögren Syndrome (SS) (1999)
1. Histopathology Definition: Positive for at least one of (A) or (B): (A) Focus score ≧ 1 (periductal lymphoid cell infiltration ≧ 50) in a 4-mm2 minor salivary gland biopsy (B) Focus score ≧ 1 (periductal lymphoid cell infiltration ≧ 50) in a 4-mm2 lacrimal gland biopsy
2. Oral Examination Definition: Positive for at least one of (A) or (B): (A) Abnormal findings in sialography ≧ Stage I (diffuse punctate shadows of less than 1 mm) (B) Decreased salivary secretion (flow rate ≦ 10 mL/10 min according to the chewing gum test or ≦ 2 g/2 min according to the Saxon test) and decreased salivary function according to salivary gland scintigraphy
3. Ocular Examination Definition: Positive for at least one of (A) or (B): (A) Schirmer’s test ≦ 5 mm/5 min and rose bengal test ≧ 3 according to the van Bijsterveld score (B) Schirmer’s test ≦ 5 mm/5 min and positive fluorescein staining test
4. Serological Examination Definition: Positive for at least one of (A) or (B): (A) Anti-Ro/SS-A antibody (B) Anti-La/SS-B antibody
Diagnostic criteria: Diagnosis of SS can be made when the patient meets at least two of the above four criteria